摘要
目的 评价希罗达 (xeloda)单药治疗复发转移乳腺癌的近期疗效和不良反应。方法 希罗达单药每天 2 5 10mg/m2 ,分早晚 2次口服 ,连续服用 2周 ,休息 1周为一个周期。每例患者至少进行 1个周期的治疗。结果 2 2例可评价疗效和不良反应的患者中 ,无完全缓解 (CR)患者 ,部分缓解 (PR) 8例 ,总有效率 36 .4%。病情稳定 (SD) 10例 ,病情进展 (PD) 4例 ,临床获益患者 (CR +PR +SD) 18例 (81.8% )。蒽环类及紫杉类治疗失败患者的有效率为 30 .0 %～ 33.3%。常见不良反应为手足综合征、皮肤色素沉着、恶心、呕吐、厌食、疲劳 ,少数患者出现口炎、头晕、腹泻和胸闷。 36 .4%的患者有轻～中度贫血和白细胞下降 ,1例Ⅳ度骨髓抑制 ,个别患者胆红素和丙氨酸转氨酶轻度升高。结论 希罗达是治疗复发转移乳腺癌患者有效的药物 ,尤其是对蒽环类及紫杉类治疗失败的患者仍有效。治疗过程中患者耐受好 ,不良反应轻。
Objective To evaluate the response rate and adverse reactions of xeloda, an analogue of 5-fluorouracil, in the treatment of relapsed and metastatic breast cancer.Methods Twenty-two breast cancer patients who had recurrent and metastatic measurable foci were treated from Dec. 1999 to Feb. 2000. Xeloda was given, as a single drug, at a dose of or 2 510 mg/m 2/d, bid, for two weeks followed by one week rest as one cycle, at least for one cycle in each patient.Results Among these 22 patients, there was no complete response. Rates of partial response 8(36.4%), stable disease 10(45.5%), progressive disease 4(18.2%), and clinical benefit response (CR+PR+SD) 18(81.8%). The response rate in patients who had failed in previous chemotherapy of taxanes and/or anthracycline was 30.0%-33.3%. The common adverse reactions were hand-foot syndrome, skin pigmentation, nausea, vomiting, anorexia and fatigue. Mild-moderate anemia and leukopenia were observed in 36.4% of patients. Stomatitis, dizziness,diarrhea and chest distress were present in some. One patient developed degree Ⅳ myelosuppression. Total bilirubin and alanine transaminase (ALAT) mild elevation occurred in a few patients.Conclusion Xeloda is an effective drug in the treatment of patients with relapsed and metastatic breast cancer, especially for those who have failed in chemotherapy with taxanes and/or anthracycline. Xeloda is well tolerated but has mild adverse reactions.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2002年第1期71-73,共3页
Chinese Journal of Oncology
