摘要
目的：探讨原发性中枢神经系统恶性淋巴瘤(PCNSL）的临床、影像学与病理学特征。方法：对18例PCNSL的临床表现、实验室结果、影像学与病理学检查进行分析。结果：PCNSL临床表现复杂，颅内高压为其主要表现之一，脑脊液中蛋白定量增高，中枢神经系统CT以及MRI检查显示肿瘤侵及额叶与颞叶多见，PCNSL主要起源于B细胞，综合治疗效果好。结论：PCNSL临床与影像学缺乏特异性表现，早期诊断困难，易被误诊，脑活组织病理学检查是确诊本病的主要手段，手术后综合放化疗可取得较好的效果。
Objective： In order to study the clinical， radiological and pathological features of primary central nervous system lymphoma (PCNSL)． Methods： The clinical， laboratory， neuroradiological and pathological data of 18 cases of PCNSL were retrospectively analysed． Results： PCNSL had complicated clinical findings of PCNSL， and increased intracranial pressure was the main clinical findings of PCNSL． Studies of CSF revealed protein elevation in excess of 1．0g／L in all of the patients． Neuroradiological examinations with CT and MRI both showed solitary or multuiple intracranial masses of tumor located particularly in the frontal and temporal lobes． The greater majority of PCNSL had been B－cell origin． Comprehensive treatment had good effects． Conclusion： The PCNSL patients usually did not show characteristic clinical manifestations or findings in imaging scanning． It is difficult to diagnose PCNSL earlier， and PCNSL could be misdiagnosed easily． A new approach in the diagnosis of this disease with the use of brain biopsy and pathological examination might be the more reliable method to confirm this disorder． Comprehensive treatment including surgery， radiotherapy and chemotherapy could achieve good effects．
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2001年第8期605-607,共3页
Chinese Journal of Clinical Oncology
