摘要
目的 :研究脑忆清胶囊对痴呆小鼠自由基代谢的影响。方法 :小鼠每日颈背皮下注射 5 % D-半乳糖 0 .5 m l,40 d可造成拟痴呆模型。在注射 D-半乳糖的同时 ,分别灌服脑忆清胶囊混悬液 7.0 ,3.5及 1.75 g/ kg3种剂量 ,并与脑复康作了比较观察。结果 :脑忆清胶囊可明显提高拟痴呆小鼠血液中超氧化物歧化酶 ( SOD)、过氧化氢酶 ( CAT)、谷胱甘肽过氧化物酶 ( GSH-Px)的活性和脑组织中 SOD活性 ,显著降低拟痴呆小鼠血清、脑组织中过氧化脂质 ( L PO)的浓度和脑中单胺氧化酶 B( MAO-B)活性 ,抑制拟痴呆小鼠脑、心、肝、肾组织中脂褐素 ( L F)的形成。结论 :脑忆清胶囊有较好的清除自由基、延缓细胞衰老和改善大脑功能的作用。
Objective: To study effect of Naoyiqing Capsule on metabolism of free redicals in dementia mice. Methods: The dementia model was induced by subcutaneous injection of 5% D-galactose on the back of the neck of mice 0.5 ml daily for 40 days. Naoyiqing Capsule was given to them orally at the dose of 7.0 , 3.5 and 1.75 g/kg, and was compared with piracetam. Results: It showed that Naoyiqing Capsule significantly increased the activities of SOD, CAT and GSH-Px in blood and the activity of SOD in brain of dementia mice, significantly decreased the concentration of LPO in serum and brain and the activity of MAO-B in brain of dementia mice, greatly inhibited the formation of LF in brain, heart, kidney and liver of dementia mice. Conclusion: These results suggested that Naoyiqing Capsule possess the reliable functions of eliminating free radical, delaying cell aging and improving the function of brain.
出处
《时珍国医国药》
CAS
CSCD
2001年第10期867-869,共3页
Lishizhen Medicine and Materia Medica Research
基金
国家药品监督局新药管理中心青年科研基金资助课题 (95- Q- 0 9)
