摘要
实验用兔,在乌拉坦静脉麻醉,自然呼吸或三碘季铵酚麻痹,人工通气条件下进行。观察了损毁或阻滞面神经核腹内侧区(VMNF)对呼吸节律的影响。结果如下:1.单侧损毁或利多卡因局部阻滞 VMNF 区可引起双侧膈神经放电时间延长,此效应在切断双侧颈迷走神经后尤为明显;2.膈神经吸气性放电的递增速度无明显改变。上述结果提示:VMNF 区在中枢呼吸节律调制中具有重要作用,可能是吸气切断机制负反馈神经元回路中的一个重要结构。
Experiments were performed on 42 urethane-anesthetized rabbits of bothsexes.The rabbits were either spontaneously breathing or gallamine paralyzed andartificially ventilated.Efferent phrenic nerve activity was recorded with bipolarsilver electrodes.The experiment results were as follows:Unilateral mechanicallesion or focal block by microinjection of lidocaine(2%,1μl)in the ventromedialregion of nucleus facialis(VMNF)consistently caused apneustic-type breathingassociated with no significant changes in the rate of rise of inspiratory activity.The-expiratory time(Te)was only slightly affected or not changed at all.Some incre-ase in Te was present only when a very strong apneustic effect was evoked.Res-piratory effects of focal block by lidocaine in the region of VMNF were not accom-partied by changes in blood pressure.No significant changes in respiratory rhythmwere observed when lidocaine is microinjected in the nearby regions of VMNF.The results suggest that VMNF appears to be involved in an inspiratoryoff-switch mechanism.
出处
《生理学报》
CAS
CSCD
北大核心
1991年第5期499-503,共5页
Acta Physiologica Sinica
关键词
呼吸节律
VMNF
切断机制
吸气
ventromedial region of nucleus facialis
respiratory rhythm
inspiratory off-switch
inspiratory activity
phase-switching
