摘要
采用高效液相色谱法测定体内氟哌酸的含量,研究了健康人口服丙磺舒和氟哌酸后氟哌酸的药物动力学变化。实验结果发现丙磺舒能抑制氟哌酸的肾排泄,但对血药水平没有影响,半衰期亦无变化。
The norfloxacin concentration in biological fluids was determined by using HPLC method with flurescence detector and the effects of probenicid on the pharmacokinetics of norfloxacin was studied in human volunteers. The results showed that probenicid could remarkably reduce the kidney elimination of norfloxacin. The half-life and AUC of norfloxacin could not be affected by probenicid. The reason remains unknown.
关键词
氟哌酸
羧苯胺
药代动力学
Norfloxacin
Probenicid
Pharmacokinetics
