摘要
目的 为临床研究肝硬化提供有价值的手段。方法 采用99mTc -RBC测定 93例肝硬化患者肝血流 ,选择峰时 (Tmax) ,半廓清时 (T1/2 )、廓清率 (K值 )、肝血流 (LBF)等作为观察指标 ,与正常对照组比较 ;同时用99mTc-MIBI经直肠给药测定其中 5 4例患者门静脉压力 (PVP) ,以心 /肝 (H/L)比值作为分流指数。结果 肝硬化组Tmax、T1/2 、K及LBF分别为 1.2 6± 0 .99(93)min、5 .75± 3.38(93)min、0 .15 4± 0 .116 (93)及 0 .6 10± 0 .2 89(93)L/min ,除Tmax外 ,与对照组均有非常显著性差异 ;Child -A、B、C级各组之间 (除Tmax外 )也均有非常显著性差异或显著性差异 ;Child -A、B、C级各组H/L分别为 0 .49± 0 .18(2 1)、0 .6 9± 0 .16 (15 )、0 .91± 0 .2 1(18) ;PVP分别为 2 .2 2± 0 .5 7(2 1)kPa、2 .85± 0 .38(15 )kPa及 3.5 4± 0 .6 5 (18)kPa。而对照组的H/L及PVP分别为 0 .30± 0 .12 (16 )及 1.6 1± 0 .38(16 )kPa。Child -A、B、C级各组分别与对照组及各组之间比较 ,除Child -B与C级组PVP无显著性差异 (P >0 .0 5 )外 ,其余均有非常显著性差异 (P <0 .0 1)及显著性差异 (P <0 .0 5 )。结论 本法测定肝血流及门脉压力方便 ,无创伤 ,对分析病情 ,判断疗效 ,指导制订治疗方案 。
Objective Providing important method for studying hepatic cirrhosis in practical medical treatment.Methods Liver blood flow (LBF) of 93 patients with hepatic cirrhosis was tested using 99m ?Tc-RBC .Peak time(T max ),Semi-time (T 1/2 ),clearance rate(K) and LBF were regarded as indicators of the experimental observation,and were compared with that in the controls.Portal vein pressure (PVP) in 54/93 patients were determined with the method of 99m ?Tc-MIBI via rectum and ratio of radioactivity in heart to liver (H/L) was used as shunt index.Results T max ,T 1/2 ,K and LBF in hepatic cirrhosis group were 1.26±0.99(93)min,5.75±3.38(93)min,0.154±0.116(93)and 0.610±0.289(93) L/min respectively.There were significant or very significant differences but for T max ;and it is so between groups of Child-A,B and C except T max .H/L of groups Child-A,B and C were 0.49±0.18(21),0.69±0.16(15)and 0.91±0.21(18),and PVP of that were 2.22±0.57(21)kPa,2.85±0.38(15)kPa and 3.54±0.65(18)kPa respectively.H/L And PVP in the controls were 0.30±0.12(16) and 1.61±0.38(16) kPa respectively.H/L of the patients was higher obviously in Child-A,B and C than that in the controls.And it is higher in Child-B than that in A and C than A respectively. As the same,PVP of Child-A,B and C were higher than that in the controls,and PVP of Child-B, C was higher than that in Child-A.Conclusion Two methods are not only convenient,but also untraumatic,and can be taken up by patients.There is unique value in the aspect of analysing patient's condition,assessing curative effect,leading to making medical plan and estimating prognosis,and so on.
出处
《苏州大学学报（医学版）》
CAS
2002年第1期34-37,共4页
Suzhou University Journal of Medical Science
