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比较不同制剂利多卡因再次硬膜外麻醉的效果

Comparison Effect of Repeated Extradural Anesthesia with Lidocaine Carbonate and Lidocaine Hydrochloride
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摘要 目的 :比较再次硬膜外麻醉时碳酸利多卡因和盐酸利多卡因的麻醉效果。方法 :135例下肢骨折内固定术后拔钉病人随机分两组 ,分别接受碳酸利多卡因 (碳利组 )和盐酸利多卡因 (盐利组 )用于硬膜外麻醉。观察两组局麻药用量、镇痛起效时间、运动阻滞程度及持续时间之间的差别。结果 :完成手术所需的碳酸利多卡因用量为 35 2 .0± 2 6 .9mg ,显著少于盐酸利多卡因的用量 389.3± 31.6mg ,且碳酸利多卡因镇痛起效时间快、运动阻滞程度强、持续时间长 ,两组相比有极显著差异。结论 Objective: To compare the effect of repeated extradural anesthesia with lidocaine carbonate and lidocaine hydrochloride. Methods: 135 patients with repeated lower limb surgery were randomized into two groups, receiving lidocaine carbonate or lidocaine hydrochloride for extradural anesthesia. Total dosage of local anesthetics, onset time, duration and degree of sensory analgesia and motor blockade were compared between the two groups.Results: A significant less total dosage of lidocaine carbonate was needed than that of lidocaine hydrochloride, which was 352.0±26.9mg and 389.3±31.6mg, respectively. Moreover, lidocaine carbonate produced a more rapid onset time of sensory analgesia and motor blockade, a longer duration of motor blockade compared with lidocaine hydrochloride when used in repeated lumbar extradural anesthesia. Conclusion: Lidocaine carbonate is superior to lidocaine hydrochloride when used in repeated lumbar anesthesia for lower limb surgery.
出处 《中国临床医学》 2001年第6期605-606,共2页 Chinese Journal of Clinical Medicine
关键词 硬膜外麻醉 局麻药 碳酸利多卡因 盐酸利多卡因 Extradural anesthesia Local anesthetic
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