摘要
为了探讨和评估Tenascin和CD34表达与人脑胶质瘤侵袭和预后的相关性 ,采用免疫组织化学和原位杂交方法 ,对 35例不同级别人脑胶质瘤组织的Tenascin及CD34表达进行检测 ,并根据患者术后随访结果进行相关性分析。结果显示 ,不同病理级别的胶质瘤胞浆内Tenascin表达或微血管密度 (MVD)具差异有显著性意义 ,随肿瘤病理级别增高 ,Tenascin表达和MVD密度越高 ,两者有显著相关性 (P <0 0 1)。Kaplan Meier生存曲线表明 ,Tenascin表达或MVD密度与人脑胶质瘤患者预后呈显著相关 ,高表达Tenascin且血管密度较高的患者预后较差。提示Tenascin及CD34与胶质瘤的侵袭性生长有关 ,检测两者对判断肿瘤患者预后有重要参考价值。
Tenascin and CD34 expression in 35 cases of human glioma with different degrees of malignancy were studied by immunohistochemistry and hybridization in situ,and their correlation analysis was conducted based on their postoperative follow up results. The expression of tenascin and microvessel density (MVD) varied with the degree of tumor cell differentiation,the higher tumor grade was,the higher tenascin expression or mvd amount was.The expression of tenascin was closely associated with angiogenesis( P <0 01).the Kaplan Meier survival curve shows that tenascin expression and MVD intensity were highly corralated with the patient′s prognosis.The patient would have a poor prognosis when the tenascin expression and density of MVD were high.It indicated that tenascin and CD34 were closely related with invasivenecs of human glioma. Therefore ,their determination might provide prognostic value in patients vvith glioma.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2002年第1期15-16,共2页
Medical Journal of Chinese People's Liberation Army
基金
国家自然科学基金资助课题 (编号 39970 85 4)
