摘要
目的 :从自由基代谢、免疫衰老两方面来验证“正虚挟瘀”是中医衰老的重要原因 /机制。方法 :两组老年小鼠连续 4周分别灌服不同的补肾健脾化瘀方药后 ,检测腹腔巨噬细胞产生的白细胞介素 1(Interleukin 1,IL 1)、脾淋巴细胞产生的白细胞介素 2 (interleukin 2 ,IL 2 )的活性 ,肝脑的脂质过氧化物 (lipidperoxides,LPO)含量以及红细胞清除自由基酶的活性 [如超氧化物歧化酶 (superoxidedismutase,SOD)、过氧化氢酶 (catalase ,CAT)、谷胱甘肽过氧化物酶 (glutathioneperoxidase ,GSH Px) ]。结果 :老年小鼠IL 1、IL 2的产生以及SOD、CAT、GSH Px均明显低于青年小鼠 ,而肝脑产生的脂质过氧化物则明显增加。给药后 ,两方均可明显调整 /恢复上述指标 ,虽然其作用强度有所不同 ,但基本上是一致的。结论 :老年机体确实存在脾肾两虚兼瘀血停滞 (正虚挟瘀 )的体质 。
Objective: To verify from two aspects of immune senescence and free radical metabolism that 'the deficiency of ZhengQi accompanied with blood stasis'is the main mechanism/cause of aging. Methods: Two groups of old mice were administered with different Kidney Supplementing Spleen Ivigorating Blood Stasis Resolving decoctions separately. After administering decoctions for 4 weeks. Interleukin 2(IL 2) producted by splenic lymphocytes, Interleukin 1(IL 1) producted by peritoneal macrophages, SOD, CAT and GSH Px in erythrocytes and LPO contents in liver and brain were detected. Results: The activities of IL 1?IL 2?SOD? CAT and GSH Px in old mice were significantly lower than those of young mice, and the LPO contents in the liver ( brain markedly increased ). Both recipes could significantly modulate/restore all indices mentioned above. The strengths of the action were different, but the effect of the two recipes were the same. Conclusion: The old organism really has the physique of deficiency of the kidney & the spleen and the blood stasis(deficiency of ZhengQi accompanied with blood stasis), hence Kidney Supplementing Spleen Ivigorating Stasis Removing is an ideal way to delay aging.
出处
《北京大学学报（医学版）》
CAS
CSCD
北大核心
2001年第6期548-551,共4页
Journal of Peking University:Health Sciences
关键词
免疫功能
中药
动物实验
药理学
自由基
代谢
补肾健脾化瘀方药5
Aging/drug eff
Free radicals/metab
Interleukin 1/anal
Interleukin 2/anal
Immunocompetence/drug eff
Kidney supplementing spleen ivigorating blood stasis removing
