摘要
目的 观察 Stargardt病多焦视网膜电图 (multi- focal electroretinogram,m ERG)变化特点。 方法 用 VERIS4.0视觉诱发反应成像系统 ,对 7例 Stargardt病患者的 14只患眼进行 m ERG测定 ,并与正常对照者的 m ERG检查结果进行比较。 结果 接受检查的所有 Stargardt病患眼的 m ERG均有显著异常 ,各部位 m ERG N1 、P1 波振幅明显降低 ,潜伏期明显延长 (P<0 .0 1) ;不同部位 N1 、P1 振幅降低程度不一致 ,以中心凹振幅降低最为显著 ,平均振幅分别只相当于正常人的 19%和 10 % ,随着离心度的增大 ,振幅差异逐渐减小 ;患者 m ERG地形图可分为中心降低型和弥漫降低型 2种形式。 结论 Stargardt病的 m ERG有明显异常改变 ,表现为黄斑中心凹功能损害最严重。
Purpose To observe the features of multi-focal electroretinogram (mERG) in Stargardt′s disease, and evaluate the validity of mERG on diagnosis of this disease. Methods mERG had been recorded in 7 cases (14 eyes) of Stargardt′s disease with VERIS 4.0,and the findings were compared with normal individuals. Results The mERG were remarkably abnormal in all cases of the disease, as the amplitudes of N 1 and P 1 waves were seriously decreased and the latencies were prolonged in all the 6 regions ( P< 0.01). The degrees of the amplitude changes of N 1, P 1 waves were not the same in those areas,and the most decreased part was in fovea. The responses of N 1, P 1 waves from the fovea of patients were about 19 and 10 percent respectively of which in controls. As the eccentricity enlarged, these differences had a tendency of reduction. The mERG topography of this disease could be divided to two types, i.e. central decreased and diffuse decreased types. Conclusion There are remarkably abnormalities on mERG in Stargardt′s disease,and the most damaged location of macular function is in fovea.
出处
《中华眼底病杂志》
CAS
CSCD
2001年第4期271-273,共3页
Chinese Journal of Ocular Fundus Diseases
