摘要
目的 :探讨低剂量新三联疗法根除幽门螺杆菌 (Hp)的临床疗效。方法 :将 80例消化性溃疡Hp阳性患者随机分成两组 ,治疗组 4 0例 ,予低剂量新三联疗法治疗 (奥美拉唑 2 0mg,qd ,克拉霉素 2 5 0mg ,qd ,阿莫西林 5 0 0mg ,bid ,共口服 1周 ) ,对照组 4 0例 ,予新三联疗法治疗 ,对比 1周后Hp根除率及 6周后溃疡愈合情况 ,随访半年后Hp再感染及溃疡的复发率。结果 :1周后低剂量新三联疗法与新三联疗法Hp根除率均为 95 % (P >0 .0 5 ) ,且溃疡愈合情况、Hp再感染及溃疡的复发率差异均无显著性。结论 :低剂量新三联疗法与新三联疗法疗效相近 ,但价格较便宜 ,易被患者接受 ,适合临床推广。
Objective: To inquire into the clinical curative effect of the low dose neo triple drug treatment in the eradication of helicobacter pylori (Hp). Methods: 80 Hp positive patients with peptic ulcers were randomly divided into two groups: the treatment group (40 patients) was subjected to the low dose neo triple drug therapy(omeprazole 20 mg+clarithromycin 250 mg, po, q.d.×7 d, amoxicillin 500 mg, po, b.i.d.×7 d) while the control group (40 patients) received the conventional neo triple drug treatment. Various parameters of the two groups were compared, including the rate of Hp eradication after 1 week of medication, the state of ulcer healing 6 weeks later, and the rate of Hp re infection and recurrence of ulcers found in a follow up study half a year afterwards. Results:After 1 week of medication, the rate of Hp eradication was the same (95%) in the two groups (P>0.05). The differences were also insignificant(P>0.05) in the state of ulcer healing, the rate of Hp re infection and ulcer recurrence between the two groups. Conclusion:The two therapeutic methods were essentially the same in terms of their efficiency. However, the low dose one seems more liable to be accepted by patients in China because it is much less costly.
出处
《医药导报》
CAS
2001年第12期739-740,共2页
Herald of Medicine
