摘要
目的 :研究P -糖蛋白 (P -gp)在肾细胞癌组织中的表达及临床意义。方法 :用免疫组化方法检测 49例肾细胞癌术前未进行化疗和 15例正常肾组织中的P -gp表达。结果 :P -gp在 15例正常肾组织中的表达率为 10 0 % ,在 49例肾细胞癌组织中阳性率 6 9.5 %。P -gp蛋白的表达与其组织学类型有关 (P <0 .0 5 ) ,与肿瘤的分化程度无关 (P >0 .0 5 )。结论 :检测P -gp对肾细胞癌病人的治疗方案选择和预后判断具有重要的临床意义。
Objective To study the expression and the clinical significance of P-glypcoprotein(P-gp) in renal cell carcinomas. Methods 49 cases of human renal cell carcinoma who were not treated by chemotheropy and 15 nomal kidney tissues were studied for the exprission of P-glycoprotein (P-gp) by means of immunohistochemistry.Results The expressions of P-gp were 100% in the normal kidney tissues the positive rate in renal cell carcinoma tissues 69.5%. There was a correlation between the expression of P-gp and histologic types ( P <0.05), and has nothing to do with the differiation of carcinomas ( P <0.05). Conclusion P-gp may have significant clinical value in the evaluation of prognosis and regimes.
