摘要
目的探讨p16癌基因蛋白表达与涎腺粘液表皮样癌分化程度的关系。方法用超敏S—P免疫组化方法检测 32例涎腺粘液表皮样癌p16癌基因蛋白的表达。结果p16癌基因蛋白阳性表达主要见于细胞浆 ,阳性率为 6 2 5 % (2 0 / 32 ) ;高分化型、中分化型和低分化型肿瘤p16癌基因蛋白表达阳性率分别为 86 6 7% (13/ 15 )、5 4 5 5 % (6 / 11)和 16 6 7% (1/ 6 )。经统计学处理 ,高分化型与低分化型肿瘤p16癌基因蛋白表达差异有显著意义 (P <0 0 1) ,高分化型与中分化型、中分化型与低分化型肿瘤p16癌基因蛋白表达差异无显著意义。结论p16癌基因蛋白表达可作为判断涎腺粘液表皮样癌组织分化程度的一个参考指标。
Objective To study relation of the expression of p16 oncoprotein to the degree of mucoepidermoid carcinoma of the salivary gland. Methods The expression of p16 oncoprotein in 32 cases was studied by immunohistochemically ultrasensitive of S P method. Results p16 oncoprotein positive staining was mainly found in the cytoplasm and positive rate was 62.5%(20/32). p16 oncoprotein positive staining was found in 13/15(86.67%) of well differentiated tumors, 6/11(54.55%) of moderately differentiated tumors and 1/6(16.67) of poorly differentiated tumors. The expression of p16 oncoprotein in well and poorly differentiated tumors was significantly different( P <0.01).Conclusion The expression of p16 oncoprotein is relative to the degree of differentiation of mucoepidermoid carcinoma of the salivary glands.
出处
《贵州医药》
CAS
2001年第11期971-972,共2页
Guizhou Medical Journal
