摘要
类风湿性关节炎(rheumatoidArthritis,RA)的发病机制十分复杂,迄今尚未阐明。近年来的研究证明,T细胞在炎症的滑膜中积聚和激活,通过分泌IFN-γ和IL-17以及细胞-细胞的直接接触,在RA炎症中发挥重要作用。此外,活化的T细胞亦可通过分泌OPGL促进RA骨损伤。提示采用调节关节内T细胞的疗法,有可能达到持久性治愈疾病的最终目标。
The pathogenesis of rheumatoid arthritis(RA)is very complex and up to now it is still not clarification.Recent studies in dicated that T cells were accumulated and activated in inflammatory synovial tissue.Those T cells contribute to the inflammation in RA by secreting IFN γand IL 17 as well as by direct cell to cell contact.Activated T cell may as well contribute to bone damage in RA by secreting OPGL.It is possible to achieve the ultimate goal of permanently switching off the disease by modulating T cells in the joint.
出处
《中国临床康复》
CSCD
2002年第1期6-7,共2页
Chinese Journal of Clinical Rehabilitation
