摘要
目的:探讨丹参酮Ⅱ A(TanⅡA)对大鼠出血性休克-再灌注肾损伤的防治作用。方法:SD大鼠 30只,分TanⅡA高、中、低剂量组、PEG组和复苏24h组,每组6只。采用修改的Yu’s法制备本实验模型,观察腹腔注射TnⅡA后的肾组织病理形态学改变和树突状细胞(DC)的分布特点,并与复苏组比较。结果:TanⅡA能减轻肾组织损伤,降低间质DC的免疫活性,二者呈正相关;而且与对照组、复苏 24 h组比较均有显著性差异(P<0.05)。结论:TanⅡA具有改善肾组织损伤、调节间质DC分布的作用,以低剂量最佳;而且后者是TanⅡA的作用机理。
Objective: To study the effect of Tan Ⅱ A against HS-RRI in rats. Methods: 30 Sprague-Dawley Rats were divided into five groups of large、middle、small dose of Tanll A,PEG400,24h after resuscitation, and each group had 6 rats. The amended model of Yu* s was maden made, then it was observed that was the effect of Tan H A by intraperitoneal injection on pathomorphology and DC. The difference was analysed between Tan HA and the 24h of resuscitation. Results: The Tan HA could improve renal pathomorphology, and adjust DC; the correlation of them was positive. The compare to the PEG and the 24h group had remarkable diffence( P< 0.05). Conclusion: Tan HA could improve renal pathomorphology and DC, the small dose was the best; and the action of DC could be its mechanism.
出处
《中国中西医结合肾病杂志》
2002年第1期13-15,共3页
Chinese Journal of Integrated Traditional and Western Nephrology
基金
广东省中医药管理局科研基金资助项目(No.99158)
关键词
丹参酮ⅡA
出血性休克
再灌注肾损伤
树突状细胞
Tanshinone-Ⅱ A Hemorrhagic shock-renal reperfusion injury dendritic cells SD-rat