摘要
目的 脑脉通注射液对全脑缺血及再灌流大鼠的脑组织皮层、间脑及延髓的单胺类递质去甲肾上腺素(NE)、多巴胺 (DA)、5 -羟色胺 (5 HT)及 5 -羟吲哚乙酸 (5 -HIAA)的影响。方法 以 4血管法造成大鼠大脑缺血模型 ,应用脑脉通注射液高剂量 (6 .6 7g·kg-1)、中剂量 (3.33g·kg-1)和低剂量 (1.6 7g·kg-1)进行治疗 ,观测其对大鼠脑组织单胺类递质含量的影响及其量效关系。结果 脑脉通注射液能显著增加缺血脑组织NE和 5 -HT的含量 ,纠正DA含量异常 ,对其代谢产物 5 -HIAA有显著的下降作用 ,以中、高剂量总体疗效更佳。结论 脑脉通注射液能显著改善缺血及再灌流后脑组织单胺递质的紊乱状态 ,降低其代谢产物。
OBJECTIVE To study effects of NMT (Naomai Tong)injection to monoamines NE, DA, 5-HT, 5-HIAA in rat's cerebral tissue in cortex , diencephalon and medulla oblongate of ischemia and re irrigation.METHODS 4 VO method is used to create the model of cerebral ischemia of rat, and treat the model with NMT injection,then,to survey the quantities of transmitters in cerebral tissue of rats and compare them, and survey the effects with high dose (6.67 g·kg -1 ) ,middle dose (3.33 g·kg -1 ) and low dose (1.67 g·kg -1 ) of NMT injection.RESULTS NMT injection could raise the quantities of NE and 5-HT , remedy the quantities of DA in cerebral tissue of ischemia obviously, and could lower the quantity of 5-HIAA distinctly. The medium and high doses have a function which is better than that of the low dose.CONCLUSION NMT injection can remedy the disorder of monoamines in cerebral tissue of ischemia and re irrigation.
出处
《华西药学杂志》
CAS
CSCD
2002年第1期13-15,共3页
West China Journal of Pharmaceutical Sciences
