摘要
为探讨妊娠期糖尿病 (GDM)患者胰岛 β细胞的功能 ,用放射免疫分析法动态观察了 41例妊娠期糖尿病患者和 30名正常妊娠对照者的血清胰岛素和C肽兴奋试验。结果表明 :孕期在 32 - 40周时 ,正常妊娠对照者与GDM患者的胰岛素和C肽兴奋水平有显著性差异 (P <0 .0 0 1) ;正常妊娠者的胰岛素分泌峰式高峰出现在6 0min ,而GDM患者的出现在 12 0min ,且恢复较正常妊娠者延长 ;C肽分泌峰式高峰时间基本上同胰岛素 ,但正常妊娠者与GDM患者的C肽峰值差比胰岛素分泌峰值差要大 ,恢复更慢。这说明GDM患者大部分胰岛 β细胞功能是良好的 ,对胰岛抵抗因素和孕期强大的应力有一定的反应 ,并提示妊娠与胰岛
To investigate the function of islet β cells in patients with gestational diabetes mellitus(GDM), serum insulin and C-peptide (C-P) excitatory test levels were measured dynamically by radioimmunoassay in 41 patients with GDM and 30 normal pregnant controls. The results showed that there were signficant difference in insulin and C-peptide excitatory test levels between normal pregnants for 32-40 weeks and patients with GDM( P <0.001). The secretory peak of insulin occurred at 60min in normal pregnants, while at 120min in patients with GDM, and the recovery postponed in patients with GDM. The peak time for C-P was just as same as that of insulin, but the peak error for C-P between normal pregnant controls and patients with GDM was more larger than that for insulin and it recovered more slowly. It suggested that majority of islet β cells in patients with GDM were good enough for response to islet resistance factors and big stress from pregnancy, and also suggested a relation between pregnancy and islet β cells function.
出处
《标记免疫分析与临床》
CAS
2001年第4期207-209,共3页
Labeled Immunoassays and Clinical Medicine
