摘要
肿瘤血管是实体肿瘤生长和转移的重要基础 ,是肿瘤治疗的新靶点。有研究表明 ,肿瘤血管内皮细胞异地表达一些抗原 ,这些抗原的抗体可介导针对肿瘤血管的靶向治疗。这种靶向治疗与针对肿瘤细胞本身抗原的靶向治疗相比有许多优势 ,动物实验研究表明 ,这种治疗对实体肿瘤有显著的破坏作用 ,且无严重毒副反应 。
The tumor vasculature is essential for growth and metastasis,and is new target in tumor treatment.Some studies have damenstrated the tumor vasculature endothelial cells expressed specifically numorous types of antigens,and antibodies against these antigens can direct the targeting therapy of tumor.This therapy has a lot of advantages over direct tumor cells targeting.Animal test damenstrated this treatment could destroy solid tumor and had slight topic response,and has postential clinical application prospect.
出处
《医学研究生学报》
CAS
2001年第6期535-537,共3页
Journal of Medical Postgraduates
关键词
抗肿瘤血管
治疗
抗体介导
毒副反应
Tumor vasculature targeting
Antibody direct targeting of tumor
