摘要
目的 :了解本地区支原体引起泌尿生道感染的状况及其药物抗性频度 ,为临床治疗支原体感染提供参考依据。方法 :取男性尿道分泌物或前列腺液和女性宫颈分泌物 ,应用 Mycoplasm a IST综合试剂盒进行支原体定量培养鉴定和药物抗性频度试验 ,同时检测沙眼衣原体 (CT)、白色念珠菌和淋球菌 (NG)。结果 :2 0 2 3例泌尿生殖道感染患者中 ,747例支原体培养阳性 ,阳性率 36 .93%;其中女性为 40 .16 %,男性为2 3.0 4%,两者差异有非常显著性 (P<0 .0 1) ;解脲支原体 (UU )感染 (4 10例 ,2 0 .2 7%)显著高于人型支原体 (MH )感染 (2 9例 ,1.43%)和 U U +MH混合感染 (30 8例 ,15 .2 2 %) (P<0 .0 1)。各年龄组支原体感染率 ,以 18～ 37岁年龄段最高 ,年龄组间差异有非常显著性 (P<0 .0 1)。 747例支原体感染患者中 ,合并 CT感染 5 9例 ,占 7.90 %,合并白色念珠菌感染 81例 ,占 10 .84%;合并 NG感染 39例 ,占 5 .2 2 %。药物抗性频度研究结果显示 :对红霉素的抗药频率最高 ,占 6 5 .2 1%,对氧氟沙星和四环素的抗药频率次之 ,分别为2 8.5 3%和 11.0 9%,对强力霉素、原始霉素和交沙霉素的抗药频较低 ,分别为 4.74%、4.17%和 1.5 2 %。比较 MH和 UU对 6种抗生素的药物抗性频度 ,MH均显著高于 U U(P<0 .0 1)。结论
Objective:To investigate the infection of mycoplasmain genitournary tract and its drug resistant to antimicrobial agents in this locality,and to provide laboratory evidence for the treatmentof mycoplasma infection.Methods:The quantitative culture of mycoplasma and its susceptibility to antimicrobial agents were examined bymycoplasma IST multiple reagent kits in urethra secretion or prostaticjujce and uterus cervix secretion.Chlamhdia trachomatis(CT)?candida albicans and neisseria gonorrhoeae(NG)were simultaneously determined.Results:The results indicated that mycoplasma was found in747 of 2023 cases(36.93%),among them the rates in the women and in the men was 40.16% and 23.04%, repectively, and the difference between them was significant(P<0.01).The infection rate of ureaplasma urealyticum(UU)was significant higher than that of mycoplasma hominis(MH) and mixed infection(UU+MU)(P<0.01),which infection frequently found were as follows:UU 410 (20.27%),MH 29 (1.43%),UU+MH308( 15.22% ).The infection rate of mycoplasma was highest in 18～37 yeargroup,and there was a significant difference between the year groups(P<0.01).Mixed infection frequently of 747 cases mycoplasmainfection found were as follows:mycoplasma+CT 59 (7.90%),mycoplasma+ candida albicans 81 (10.84%),mycoplasma+NG 39 (5.22%).The drug resistantfrequently to antimicrobial agents showed that to erythromycin was highest(65.21%),to ofloxacin and tetracycline subsequently (28.53%?11.09%,respectively),but to doxcycline?pristinomycin and josamycin was low(4.74%?4.17%and 1.52%,respectively).The resistant frequentlyof MH to 6 antimicrobial agents was significant higher than that of UU(P<0.01).Conclusions:Mycoplasma is one of majorpathogen of genitournary tract infection.Now,josamycin and doxycyclineare drug of first choice in treatment of mycopasma infection if this locality.One should note mixed infection in dignosis of disease.
出处
《中国微生态学杂志》
CAS
CSCD
2001年第6期356-357,共2页
Chinese Journal of Microecology
关键词
泌尿生殖道
支原体感染
药物抗性
频度
Genitourinary tract
Mycopasma infection
Drug resistant frequently
