摘要
目的 :对非小细胞肺癌(NSCLC)准确和早期的诊断在临床治疗中是非常必要的。材料和方法 :我们把98例临床拟诊NSCLC患者及22例肺癌术后患者肺部CT扫描、全身FDGPET显像与病理结果进行回顾性的分析 ,并与病理结果对照研究PET对鉴别肺部孤立性结节的性质、判断远处转移的准确性进行分析以及PET在NSCLC诊断中的某些特殊情况的优越性。结果 :FDGPET对NSCLC总的诊断的灵敏度和特异性为96.9 %和86.6 %,CT总的灵敏度和特异性为74.6 %和80 %。其中33例肺部孤立性结节患者中 ,23例恶性病变出现局部FDG浓聚(SUV=4.7±2.2) ,明显高于良性病变(SUV=1.2±1.2) ,其中7例可观察到一侧纵隔的转移 ,15例患者尚可见肺门病灶伴胸内转移 ,PET所示病灶数目明显多于CT。在判断22例术后患者NSCLC复发的灵敏度和特异性为92.3 %及88.9 %,均高于同期的CT。此外 ,对于有其他检查有困难的患者(如大量胸水等) ,PET是寻找肿瘤病灶的最佳检测手段。结论 :FDGPET在对NSCLC的诊断优于解剖显像 ,通过PET全身显像 ,可以及早发现早期转移灶 ,避免对已属晚期的患者盲目进行手术治疗。在肺癌术后随访可提供有价值的参考信息。但PET在精确定位方面仍然需要结合解剖显像 ,图像融合技术等是发展的方向。
Purpose:Correct diagnosis of non-small cell lung cancer(NSCLC) is essential for clinical management.Materials and Method:We investigated the sensitivity and specificity of FDG PET(positron emission tomography) imaging in the diagnosis of NSCLC.A retrospective study was carried out in 120 cases(98 pre-surgery patients and 22 post-surgery) who had undergone whole body PET scanning and computed tomography(CT);Among these patients,we evaluated the role of FDG PET in identifying solitary pulmonary nodules(33 cases),Mediastinal nodal staging and extrathoracic metastasis.Results:Sensitivity and specificity for the diagnosis and staging of NSCLC were 96.9% and 86.6% for PET and 74.6% and 80% for CT.In 33 patients with solitary pulmonary nodules which found by CT,the whole body FDG PET was performed to identify 23 patients with malignant nodules.The standard uptake value(SUV=4.7±2.2),it was clearly higher than benign nodules(p<0.05).Conclusions:Imaging with PET was more accurate method than CT for diagnosis of solitary pulmonary nodules,mediastinal and distant metastasis.It can make early detection of unsuspected staging and may permit reduction in the number of operation undergo for nonrectable disease.
出处
《中国医学计算机成像杂志》
CSCD
2001年第5期346-348,共3页
Chinese Computed Medical Imaging
