摘要
目的 :探讨膀胱透明细胞癌的临床和病理特点。方法 :报告 3例膀胱原发性透明细胞癌的诊治情况并复习有关文献。结果 :病理观察透明细胞取代移行上皮细胞 ,并呈现出各种结构包括腺管囊状、乳头状弥漫分布 ,并显示明显的核的非典型性 ,核分裂数多见。有肿瘤组织的部分坏死 ,2例见有膀胱肌层浸润 ,临床特点主要为尿痛、血尿及排尿困难。结论 :膀胱原发性透明细胞癌的组织病理学特点为较多的透明细胞 ,丰富的细胞浆内的糖原 ,重度细胞的非典型性 。
Objective: Our aim was to discuss the clinical and pathological features of clear cell adenocarcinoma of the urinary bladder. Methods: Three cases of the primary clear cell adenocarcinoma of bladder were presented with a review of literature. Results: Microscopic examination revealed that clear cell replaced transitional cell and showed a variety of patterns, including tubular glands, cysts papillae and diffuse areas. Showing significant nuclear atypia and mitotic activity. Cell with abundant glycogen rich clear cytoplasm and hobnail cells were identified in most of the tumors. Two cases showed invasion of the muscle of the bladder wall and partial necrosis of the tumor tissue. The clinical features were irritative voiding symptoms, hematures, and dysuria. Conclusion: The histopathologic features of clear cell adenocarcinoma of the bladder include a predominance of clear cells, abundant intracytoplasmic glycogen, severe cytological atypia, invasion of the muscle of the bladder wall and hobnail cells were prominent.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2001年第6期463-464,467,共3页
Journal of China Medical University
关键词
膀胱肿瘤
透明细胞癌
病理学
bladder neoplasms
clear cell adenocarcinoma
pathology
