摘要
目的 观察红霉素、西沙比利的促胃肠动力作用及其对新生儿喂养困难的改善情况。方法 收集 1997年 11月至 1999年 2月共 41例喂养困难的新生儿病例。分两组 ,分别用红霉素 (3～ 5mg/(kg·d)静脉点滴 )和0 .1%的西沙比利悬液 (0 .2～ 0 .3mg/(kg·次 ) ,tid ,餐前口服 )进行干预治疗。通过用药前后胃食管显像和血胃肠激素的变化观察药物疗效。结果 红霉素干预组 (n =2 7)干预期 (7.8± 2 .2 )d ,用药后 6 0min胃排空率 (GE60 % )从(2 2 .9± 12 .6 ) %升至 (38.7± 17.1) % ,反流指数 (RI)从 16 .9± 9.4降至 8.1± 5 .7,P值均 <0 .0 0 1;血浆胃动素水平显著上升 ,从 (5 83.2± 2 5 3.1)升至 (90 7.5± 30 1.1) pg/ml(P <0 .0 0 1) ;血清胃泌素浓度变化不明显 [(5 2 .8± 12 .9)升至 (5 8.7± 2 0 .4) pg/ml,P >0 .0 5 ]。西沙比利组 (n =14)干预期 (9.4± 2 .7)d ,GE60 %从 (2 6 .2± 14.7) %升至 (40 .0±17.4) % ,RI从 17.3± 11.4降至 7.2± 3.5 ,P均 <0 .0 1;但血胃泌素和胃动素水平用药前后变化不明显 [分别是(5 3 .5± 13.7)对 (5 9.3± 13.5 ) pg/ml,(771.1± 2 32 .2 )对 (878.4± 2 5 3.3) pg/ml,P均 >0 .0 5 ]。两种药物在患儿完成奶量方面无显著差异 [(176 .2± 49.4)和 (197.5± 35 .8)
Purpose: To investigate the effects of erythromycin and cisapride promoting neonatal gastrointestinal motility and improving neonatal feeding. Methods: During the year of Nov. 1997 to Feb. 1999,41 hospitalized neonates which were suffered from feeding problems were studied. Erythromycin (3-5)mg/(kg·d) by intravenous infusion and 0.1% solution of cisapride (0.2-0.3)ml/kg, three times a day by oral were used in our study. Gastroesophageal scintigraphy and radioimmuno assay were measured before and after the intervention. Results: 27 neonates were treated with erythromycin for (7.8 ± 2.2) d, after that GE60% was increased from (22.9 ± 12.6)% to (38.7+17.1)%, RI was decreased from 16.9 ± 9.4 to 8.1 ± 5.7, P 0.05].14 neonates took cisapride for (9.4 ± 2.2) d, GE60% was increased from (26.2 ± 14.7)% to (40.0 ± 17.4)%, RI was decreased from 17.3 ± 11.4 to 7.2 ± 3.5, (P 0.05). There were no obvious side effects of the two drugs in this study. Conclusions: Erythromycin and cisapride can promote neonatal gastrointestinal motility and improve their feeding. How to choose these drugs depends on the specific situations.
出处
《复旦学报（医学版）》
EI
CAS
CSCD
北大核心
2001年第5期422-424,共3页
Fudan University Journal of Medical Sciences
