摘要
目的 观察“支撑者”支架的性能、疗效,以求研制成技术性能达标的国产化支架。方法(1)急性血栓形成检测:雄性新西兰白兔10只,骼动脉支架植入术后24 h行骼动脉造影术。(2)中远期疗效检测:雄性新西兰白兔20只,给子高胆固醇饲料(4%胆固醇)饮食1个月后行骼动脉支架植入术。随机分为2组:①30天组10只,于术后1个月行骼动脉造影术。②60天组10只,术后2个月行骼动脉造影术。30天组9只动物完成实验,60天组8只动物完成实验。结果(1)共27只兔完成实验,27个支架植入成功23个(成功率85.2%)。(2)急性血栓形成检测:10个支架,9个完全张开,未见血栓形成,血流TIMI Ⅲ级。1个脱落。(3)中远期疗效检测:①30天组(n=9):7个支架在骼动脉完全张开,1个在腹主动脉下段完全张开,末见血栓及狭窄,血流TI-MIⅢ级,1个脱落。②60天组(n=8):6个支架完全张开,未见狭窄,2个脱落。(4)无其他井发症发生。结论“支撑者”支架性能稳定,没有出现支架内急性、亚急性血栓形成和狭窄。
Abstract: Objective To observe the propertiesand effects of supporter stent whether they were suitablefor the clinic requirements. Methods Tests of acutethrombosis of the devices: Ten supporter stents were re-spectively implanted right or left iliac artery of ten maleNew Zealand white rabbits. Angiographies were performedin 24 hours. (1) Examinations of 30~60 days effects ofthe devices: twenty male New Zealand white rabbits fedwith hypercholesterol diet were randomized to two groupsfor stenting in right or left iliac artery: (1)Day 30 group(n=10): one month after the procedures, angiographieswere done.(2)Day 60 group (n = 10): two month afterthe procedures, angiographies underwent. 9 animals ar-rived at the end of the experiments in the Day 30 groupand so did 8 in the Day 60 group. Results (1)23 of 27stents were implanted successfully (85. 2%). (2) Testsof acute thrombosis: 9 stents opened completely withoutthrombus, and one lost. (3) The middle and long exami-nations: (1)the Day 30 group (n = 9):7 stents openescompletely in iliac artery and one opened in the inferiorabdominal aorta without acute or subacute thrombosis.Another one lost.(2)the Day 60 group (n=8):6 stentsopened completed without stenosis and 2 lost. (4) No oth-er events occurred in the periods. Conclusion The pro-perties of supporter stent were stable, and there were noacute or subacute thrombosis, and stenosis in the stents inthe observational periods.
出处
《岭南心血管病杂志》
2001年第6期431-433,共3页
South China Journal of Cardiovascular Diseases
基金
广东省科委百项创新项目
编号:99B06702G