摘要
目的比较血清心肌肌钙蛋白与血清CK -MB水平诊断心肌炎性损伤的敏感性和特异性。 方法建立急性病毒性心肌炎小鼠模型 ,测定小鼠血清心肌肌钙蛋白I(cTnI)、心肌肌钙蛋白T(cTnI)及肌酸激酶MB同工酶(CK -MB)水平 ;同时观察 42例临床拟诊急性病毒性心肌炎患者血清肌钙蛋白及血清CK -MB水平。 结果 2 8只病鼠中 19例 (6 7.85 % )cTnI升高 ,17例 (6 0 .71% )cTnI升高 ,6例 (2 1.42 % )CK -MB升高 ;42例患者中 2 6例 (6 1.9% )cT nI升高 ,16例 (38.1% )cTnT升高 ,2例 (4 .76 % )CK -MB升高。 结论测定血清肌钙蛋白水平探查心肌炎性损伤远较血清CK
Objective To investigate systematically whether cardiac troponin I and T and CK-MB are useful for the diagnosis of inflammatory heart disease. Methods A murine models of acute viral myocarditis were established. cTnI and cTnT were first measured in these mice. On the basis of animal experiments, we proceeded to measure the markers in the sera from 42 patients with acute myocarditis. Results Among the 28 mice and 42 patients with myocarditis, 19 mice and 26 patients were found to have elevated cTnI values, 17 mice and 16 patients had elevated cTnT values, but CK-MB values were only elevated in 6 mice and 2 patients. Thus, the frequency of a positive cardiac troponin level was significantly greater than a positive CK-MB value to diagnose inflammatory heart disease (P<0.02). Conclusion cTnI and cTnT were superior to CK-MB for the detection of myocyte injury in myocarditis.
出处
《上海第二医科大学学报》
CSCD
2001年第4期338-340,共3页
Acta Universitatis Medicinalis Secondae Shanghai
