摘要
线粒体是细胞内重要的细胞器 ,是生成ATP的主要场所 .线粒体通透性改变孔道 (PT孔道 )的开放会引起线粒体许多功能的紊乱而导致细胞死亡 .对茶多酚及其单体儿茶素对过氧化氢诱导的线粒体膨胀及膜电势变化过程中PT孔开放的影响进行了研究 .实验结果表明茶多酚及其儿茶素单体对PT孔开放的影响显著不同 :茶多酚及其主要成分EGCG和ECG能够有效地抑制PT孔道的开放 ;而ECG ,(+) C和EGC却加速PT孔道的开放过程 .从总体效果来看 。
Mitochondria are important intracellular organelles in which energy is generated. Mitochondrial permeability transition pore (PTP) opening will induce mitochondrial dysfunction, then result in cell death. The study was carried out to investigate the influence of green tea polyphenols (GTPs) and five kinds of catechins on mitochondrial PTP opening. The results showed that GTPs and catechins have obvious and different effects on H2O2-induced mitochondrial PTP opening. GTPs and its major components EGCG, ECG have inhibitory effects on it, while other kinds of catechins, EGC, EC and (+)-C can accelerate the process. The data provide an alternate interpretation of the potent protective function of GTPs, EGCG and ECG.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2001年第6期890-894,共5页
Progress In Biochemistry and Biophysics
基金
国家自然科学基金资助项目 (2 99350 80 )~~
