摘要
研制冻干甲肝减毒活疫苗 ,提高疫苗的稳定性 ,便于保存及运输 ,保证疫苗的接种效果。采用CA 9冻干保护剂 ,按 1∶3.5的比例加入疫苗 ,制备冻干疫苗。冻干甲肝减毒活疫苗具有与液体疫苗相同的安全性及免疫原性。在 2～ 8℃保存的有效期较液体疫苗的 3～ 5个月提高到 18个月。在室温和 37℃保存的稳定性也明显提高。冻干甲肝减毒活疫苗的稳定性良好 ,无需低温保存、冷链运输 。
Lyophilized attenuated live hepatitis A vaccine was studied for raising its stability in order to store and transport and for guarantee its vaccination effect. CA 9 freeze dried protection agents were added to the vaccine with the ratio of 1: 3.5. The vaccine has the same immunogenicity and security as liquid vaccine. The valid period after storage under 2～8℃ raised from 3～5 months of liquid vaccine to 18 months of the vaccine. The stability in room temperature was also remarkably improved. Therefore, lyophilized attenuated live vaccine of hepatitis A vaccine has good stability, no need to store in low temperature and to transport with cold chain. It is good for spreading its application in large scale.
出处
《微生物学杂志》
CAS
CSCD
2001年第4期1-4,共4页
Journal of Microbiology
