摘要
目的 观察复合脉冲电磁场 (PEMFs)对去卵巢大鼠骨质疏松 (OP)的预防作用 ,以寻求防治OP的新途径。方法 3月龄SD大鼠随机分为正常对照组 (N)、去卵巢组 (O)、去卵巢加苯甲酸雌二醇处理组 (E)及去卵巢加PEMFs处理组 (EM) ,治疗 8周后测定骨生物力学、骨密度、骨形态学。结果 生物力学性能测定显示 ,经PEMFs治疗后股骨最大抗拉强度和椎骨最大抗压强度明显提高 ,较O组分别增加 39 2 %、37 9% (P <0 0 1) ,并超过N组和E组 (P <0 0 1) ;EM组骨密度 (BMD)尽管未恢复至正常 (P <0 0 5 ) ,但与 0组相比仍有明显改善 (P <0 0 1) ,且已基本达到E组水平 ;骨形态学分析发现EM组骨小梁增宽、致密 ,分布有序 ,结构优于 0组和E组。结论 PEMFs能够增加骨密度 ,改善骨生物力学性能和骨结构。鉴于其对OP的预防作用主要是通过提高骨质量来实现的 ,我们认为在PEMFs一定程度上优于苯甲酸雌二醇 。
Objective\ To investigate if pulsing electromagnetic fields(PEMFs)can prevent osteoporosis in ovariectomized (OVX) rats. Methods\ Female adult SD rats were divided randomly in to normal control(CN),ovariectomized (O),OVX plus estrogen treated (E),and OVX plus PEMFs treated (EM) groups.The biomechanical characteristics,bone density and bone morphology were detected to evaluate the difference between threeOVX groups and normal control group. Results\ Compared with N group,the biomechanical characteristics and BMD in O group both decreased significantly ( P <0 01).Treatment with PEMFs showed not only better biomechanical characteristics and significantly higher BMD than 0 group( P <0 01),but also better biomechanical properties than N and E groups ( P <0 01),although BMD in EM group did not reach normal ( P <0 05).In addition,the trabeculae in EM group determined by bone morphology were thicker and denser than those in other groups,and the appearance and arrangement of trabeculae in EM group were regular. Conclusion\ PEMFs can reduce the bone loss,improve the biomechanical properties of the bone and prevent osteoporosis in OVX rats.Its effect seems better than estrogen,at least in bone quality.
出处
《中国骨质疏松杂志》
CAS
CSCD
2001年第3期224-227,共4页
Chinese Journal of Osteoporosis
关键词
复合脉冲电磁场
去卵巢大鼠
骨质疏松
雌激素
骨密度
Pulsing electromagnetic fields
Ovariectomized rats
Osteoporosis
Estrogen
\ Prevention
