摘要
非甾体抗炎药 (non steroidalanti inflammatorydurgs,NSAID)在临床上的应用非常广泛 ,用于治疗类风湿性关节炎、骨关节炎及其他风湿性疾病 ,其常见不良反应主要有胃肠道损害、肾脏损害、肝脏以及血液等系统损害。其发生机制与抑制前列腺素合成有关 ,预防或减弱NSAID不良反应的措施是合理用药、避免NSAID滥用、使用胃黏膜保护剂等。今后NSAID发展的方向应是选择性COX 2抑制剂、NO释放型NSAID以及选择性COX 2 / 5
Non steroidal anti inflammatory drugs(NSAID) are among the most widely prescribed medications, primarily for treatment arthritis. Their use is limited by significant toxicity, particularly vin the gastrointestinal tract and kidney. The pathogenesis of NSAID induced gastropathy is related to two main mechanism: an initial topical effect which is PH dependent and a systemic effect which is , more slowly developing and mainly correlated to the inhibition of prostaglandin synthesis. Many new NSAID are not only less toxic but more efficacious, such as selective COX 2 inhibitors, NO releasing NSAIDs and selective COX 2/5 Lox dual inhibitors.
出处
《安徽医药》
CAS
2001年第3期161-163,共3页
Anhui Medical and Pharmaceutical Journal
