摘要
目的 :探讨氯沙坦、福辛普利和硝苯地平控释剂对原发性高血压患者诊所血压及昼夜血压的影响 ,并进行比较。 方法 :87例轻、中度原发性高血压患者随机分为 3组 ,分别服用氯沙坦 5 0mg/d (L组 ,30例 )、福辛普利 10mg/d (F组 ,2 8例 )和硝苯地平控释剂 30mg/d (N组 ,2 9例 ) ,比较治疗前及治疗 4周末对诊所血压 (OBP)、动态血压的影响。 结果 :3组治疗 4周末OBP、动态血压均较服药前降低 ,有显著性差异 (P <0 0 5～ 0 0 0 1) ,3组间无显著性差异 ;各组均能维持正常的血压昼夜节律 ,2 4小时血压谷 /峰 (T/P)均大于 70 %;以N组作用显著。各组不良反应发生率分别为F组 39 4 %、N组 43 8%、L组 18 2 %,N组 2 4小时平均心率较治疗前明显加快 (P <0 0 5 )。 结论 :氯沙坦、福辛普利和硝苯地平控释剂均能有效持续降低血压。治疗后硝苯地平控释剂 2 4小时血压谷 /峰优于氯沙坦和福辛普利。氯沙坦服药后的耐受性优于福辛普利及硝苯地平控释剂。
Objective:This study was aimed at investigation and comparison of effects of losartan,fosinopril and adalat gartro-intestinal therapeutre system (GITS) on office blood pressure (OBP) and ambulatory blood pressure (ABP) in patients with essential hypertension(EH). Methods:Eighty-seven patients with mild to moderate EH were studied.Patients with EH were randomly divided into three groups and were treated with adalat GITS 30*!mg/d (N group,n=29),fosinopril 10*!mg/d(F group,n=28)or losartan 50*!mg/d(L group,n=30)respectively.The Changes of OBP and ABP were compared before and four weeks after treatment. Results:Side effects were 18.2% in L group,39.4% in F group and 43.8% in N group,respectively.OBP and ABP in the three-group patients were all significantly reduced after four-weeks treatment (p<0.05-0.01).The antihypertensive effects among the three different medicines had no statistical differences.Each medicine could keep normal circadian rhythm of blood pressure.The trough to peak ratios were all above 70%.Adalat GITS was superior to the others in T/P ratio,but the average heart rate of 24 hours in N group was more rapidly than before(p<0.05). Conclusion:All the three antihypertensives can significantly and safely decrease blood pressure.Adalat GITS is superior to the others in T/P ratio.Losartan is superior to the others in drug tolerance.
出处
《中国循环杂志》
CSCD
北大核心
2001年第5期328-330,共3页
Chinese Circulation Journal
关键词
氯沙坦
福辛普利
硝苯地平控释剂
高血压
动态血压监测
Losartan
Fosinopril
Adalat gartro-intestinal therapeutre system
Hypertension
Ambulatory blood pressure
