摘要
目的 探讨孤独症与5-HT基因和APOE基因之间的关系。方法 应用PCR-RFLP技术对符合国际疾病分类第10版(ICD-10)中孤独症诊断标准的21例孤独症患儿和他们的父母进行了5-HT2a,5-HT6和APOE多态性的检测。结果 孤独症患儿与对照组5-HT2a,5-HT6和APOE的基因频率和基因型频率的分布呈基本一致的趋势,两组间未显示具有统计学意义的差别。采用基于单体型的单体型相对风险率分析方法,发现仅5-HT6基因中T等位基因与孤独症显著关联(RR=3.59,P<0.05)。传递不平衡检验(TDT)发现孤独症可能与5-HT6中T等位基因相连锁(McNemarX^2=5.4,P<0.05)。结论 5-HT6基因与孤独症的发病可能存在关联或连锁关系。
Objectives: To explore the relation between autism and 5-HT gene and APOE gene. Method: The polymorphisms of 5-HT gene and apolipoprotein E gene in blood cell were examined with PCR-RFLP in 21 children who met ICD-10 autism criteria and their parents. Results: There were no differences of gene expression of 5-HT2a, 5-HT6 and APOE between autistic children and their parents. There were a significant association between autism and allele T of 5-HT6 (RR = 3. 59, P<0. 05). With transmission/disequilibrium test(TDT) analysis, we found that there was a linkage association between autism and allele T of 5-HT6 (x2 = 5. 4, P<0. 05). Conclusion: It is possible that there were a association between allele T of 5-HT6 gene and autism.
出处
《上海精神医学》
北大核心
2001年第3期130-133,共4页
Shanghai Archives of Psychiatry
基金
上海市卫生局科技发展基金(98411)
