摘要
目的了解一氧化氮 (NO)对周期性麻痹患者发病的影响。方法低钾型周期性麻痹患者 ,在弛缓性瘫痪发作期及肌力恢复后 ,同时检测血钾、NO、一氧化氮合酶 (NOS)。观察不同病期患者血 NO、NOS的变化与疾病的关系。结果 42例患者在瘫痪发作期血 NO、NOS均明显降低 ;经治疗后 ,NO、NOS随血钾和肌力的恢复而趋于正常。瘫痪期 NO的变化与血钾降低的程度呈正相关 (r=0 .3 5 11,P<0 .0 5 ) ;与肌无力程度无明显相关。结论 NO参与了周期性麻痹患者弛缓性瘫痪的发病。
Objective To find out the effect of NO on the stroke of periodic paralysis.Methods Blood potassium,NO and NOS were measured in patients with hypokalemic periodic paralysis during paralysis stroke and after muscle power recovered.The relationship between NO and NOS and paralysis in the different phase was observed.Results NO and NOS decreased obviously in the phase of paralysis,which tended to be normal with recovering of blood potassium and muscle power after treatment.The change of NO was positively correlated with the decreasing degree of blood potassium(r=0.3511,P<0.05),which had no obvious correlation with myasthenia during paralytic phase.Conclusion NO has participated in the periodic paralysis stoke.The mechanism is likely to operate the potassium passage to reduce blood potassium.
出处
《中国综合临床》
北大核心
2001年第7期509-510,共2页
Clinical Medicine of China
