摘要
目的 : 探讨重症药疹的致病药物、临床特征及疗效相关因素。方法 : 回顾性分析 6 8例重症药疹患者临床资料 ,并与同期住院 16 5例非重症药疹患者进行比较。结果 : 6 8例患者男女之比为1:1.1,平均发病年龄为 41.9± 2 1.2 ,皮质类固醇治疗剂量相当泼尼松 1.79± 1.0 1mg kg d ,痊愈率83.8%。与非重症药疹相比 6 0岁以上发病率、致病药物、高烧、并发症和粘膜损害的发生率、皮质类固醇治疗剂量、治愈率有明显差异 (P <0 .0 1)。诱发因素为误诊、再次服用致病药物及治疗不利。结论 :重症药疹老年人发病率高 ,致病药物最常见的是解热镇痛药 ,影响疗效的主要因素是并发症 。
Objective:To analyze the clinical signs, involved drugs and factors relating to curative effect in patients with severe drug eruption.Methods:Clinical data from 68 cases of severe drug eruption were compared with those of 165 cases of nonsevere drug eruption retrospectively.Results:The male to female rate was 1:1.1 and the mean age of morbidity was 41.9±21.2 in the severe drug eruption group. Corticosteroid dosage was 1.79 ±1.01 mg/kg/d (correspondent to prednisone) and the curative rate was 83.8%. There were significant differences between severe and nonsevere groups of morbidity in patients over 60 years old, in terms of involved drugs, incidence of high fever, complications, steroid dosage and cure rate (P<0.01). The inducing factors of severe drug eruption were misdiagnosis, repeatedly taking involved drugs and inappropriate treament. Conclusions :The incidence of severe drug eruption in old people is higher, and most common involved drugs are antithermic agents. Therapeutic effectiveness is mainly correlated with complications. Early and sufficiently using corticosteroids is important to reduce the mortality.
出处
《中国麻风皮肤病杂志》
北大核心
2001年第3期164-167,共4页
China Journal of Leprosy and Skin Diseases
关键词
重症药疹
诊断
治疗
severe drug eruption
curative effect
