摘要
目的 :探讨低水平铅暴露对学龄前儿童免疫球蛋白 Ig E的影响。方法 :用石墨炉原子吸收光谱法对 2 1 7名学龄前儿童进行血铅浓度筛查 ,用酶联免疫吸附试验 ( ELISA)检测不同血铅水平对学龄前儿童免疫球蛋白 Ig E的影响。结果 :高铅组 (血铅≥ 0 .48μmol/L)学龄前儿童Ig E水平与低铅组 (血铅 <0 .48μmol/L)比较具有升高趋势 ,但无统计学意义 ( P>0 .0 5 ) ;高铅组血铅浓度与 Ig E水平呈正相关 ( r=0 .5 0 ,P<0 .0 1 ) ;女童高铅组 Ig E水平与低铅组比较显著升高 ( P<0 .0 5 )。结论 :铅中毒具有刺激学龄前儿童 Ig E的产生 ;铅暴露对学龄前儿童 Ig
Objective:To study the effects of lead exposure on immunoglobulin E in preschool children.Methods:Blood lead levels were measured in 217 preschool children by graphite furnace atomic absorption spectrophotometry.and IgE of different blood lead levels were analysed by ELISA.Results:No statistically significant differences between groups of high and low blood lead levels were found (P>0 05).A statistically significant relationship of IgE and blood lead level was found in high blood lead group (r=0.50,P<0 01).IgE levels of female children were increased in the high blood lead level group (P<0 05).Conclusion:Low level lead exposure could play a role in this process by stimulating IgE prduction in children.The effect of lead on IgE was stronger in girls than in boys.
出处
《微量元素与健康研究》
CAS
2001年第3期27-29,共3页
Studies of Trace Elements and Health
基金
浙江省卫生厅资金资助项目 (2 0 0 0 A0 61 )
