摘要
目的 比较不同胰岛素给药方法对高血糖治疗差异。方法 2 6例需胰岛素治疗的高血糖病人住院进行了两种胰岛素强化治疗。⑴胰岛素泵连续皮下治疗 (CSⅡ组 :1型DM 4例 ,2型DM 2例 ) ;⑵多次皮下注射胰岛素治疗 (MSⅡ :1型DM 3例 ,2型DM 17例 )。二组治疗目标血糖值均为三餐前血糖及睡前末梢血糖≥3 6mmol/L且≤ 7 2mmol/L并至少 3d。结果 二组病人最终均达到了目标血糖值 ,但CSⅡ组更接近正常水平 ,平均高血糖控制天数有显著性差异。CSⅡ组 :(8 3± 1 3)d ,MSⅡ组 :(13 6± 2 4 )d ,(t =5 136,P <0 0 5 )。胰岛素用量无显著性差异。CSⅡ :(4 3 4± 8 4 )u/d ,MSⅡ :(4 7 2± 8 7)u/d ,(t =0 94 5 ,P >0 0 5 ) ,而CSⅡ组低血糖发生率低于MSⅡ组 ,CSⅡ :(0 67± 1 3)次 /人 ,MSⅡ :(2 15± 1 4 )次 /人 ,(t =2 30 5 ,P <0 0 5 )。结论 CSⅡ组可较MSⅡ组更快更有效控制高血糖 。
Objective To compare the effects of two different approaches of insulin delivery on hyperglycemia.Methods 26 poorly controlled diabetic patients were studied by two methods of intensive insulin delivery.⑴Continuous subcutaneous insulin infusion(CSⅡ) group(n=6),including 4 cases of type 1 DM,2cases of type 2 DM;⑵Multiple subcutaneous insulin injection(MSⅡ) group(n=20),including 3 cases of type 2 DM,17 cases of type 2 DM.The target BGs for both groups were premeal and bedtime BG3≥3 6mmol/L ≤7 2mmol/L for at least 3 days.Results Both groups had reached the target BGs,the CSⅡ groups more close to normal level.The average durations of treatment were significantly different;CSⅡ(8 3±1 3)d,MSⅡ(13 6±2 4)d for the two groups (t=5 136,P<0 05),The insulin dosage not significantly different.CSⅡ(43 4±8 4)u/d,MSⅡ(47 2±8 7)u/d(t=0 945,P>0 05).The hypoglycemia incidence in CSⅡ was(0 67±1 3)time/case,in MSⅡ(2 15±1 4)time/case(t=2 305,P<0 05).Conclusion MSⅡ could control the hyperglycemia much faster and more effectiveness,and reduce the hypoglycemia risk.
出处
《中国医师杂志》
CAS
2001年第9期574-575,共2页
Journal of Chinese Physician
关键词
胰岛素泵
治疗
皮上注射
糖尿病
Insulin,pump
Subcutaneous,injection
Treatment
Hyperglycemia
