摘要
目的 :探讨 HBIG-HBVac复合物消除慢性乙型肝炎免疫耐受和治疗慢性乙型肝炎的可能机理。方法 :采用EL ISA法检测 10例慢性乙型肝炎患者 HBIG-H Bs Ag复合物和 HBs Ag诱导的外周血单个核细胞 γ-干扰素反应。结果 :H BIG-HBs Ag复合物和 HBs Ag刺激的慢性乙型肝炎患者外周血单个核细胞上清液中仅 1例可测出 γ-干扰素 ;以 P/N≥ 2 .0为标准 ,HBIG-HBs Ag复合物和 HBs A g刺激的外周血单个核细胞上清液中各仅 1例阳性。结论 :HBIG-H Bs Ag复合物不能更有效地诱导细胞免疫反应。
Objective: It is to investigate the probable mechanisms that HBIG HBVac complexes eliminate the immunologic tolerance of chronic hepatitis B. Methods: HBIG HBsAg complexes and HBsAg induced γ interferon responses by peripheral blood mononeuclear cells in 10 patients with chronic hepatitis B were examined by ELISA. Results: Only one patient produced detectable γ interferon responses in the supernatants by the cultured peripheral blood mononeuclear cells stimulated by HBIG HBsAg complexes and HBsAg. Only one patient respectively produced positive (P/N ≥2.0) γ interferon responses by HBIG HBsAg complexes and HBsAg. Conclusion: HBIG HBsAg complexes induced γ interferon responses by peripheral blood mononeuclear cells in patients with chronic hepatitis B were not more effective than HBsAg.
出处
《现代中西医结合杂志》
CAS
2001年第12期1099-1100,共2页
Modern Journal of Integrated Traditional Chinese and Western Medicine
