摘要
目的 :制备洛伐他丁缓释片 ,以降低其不良反应。方法 :采用正交设计对处方进行优化 ,并在人工胃液和人工肠液中考察了优化处方的溶出情况。结果 :洛伐他丁缓释片在 2、8、14h的累计百分释放度分别为 11 97%、5 6 4 2 %、82 15 %。结论
OBJECTIVE:To prepare Sustained release lovastatin tablets METHODS:Orthogonol design was used to optimize the formulation and the release character was also studied in artificial gastric juice and intestinal juice.RESULTS:The cumulative release percentage of sustained release was 11.97%,56.42%,82.15% respectively at 2 hour,8 hour and 14 hour.CONCLUSION:The release of Lovastatin sustained release tablets in vitro accord with the first class equation
出处
《华西药学杂志》
CAS
CSCD
2001年第4期265-266,共2页
West China Journal of Pharmaceutical Sciences
