摘要
目的 评价胃酸分泌增加对反流性食管炎的影响。方法 内镜检查和食管内 2 4hpH监测确诊的食管炎患者 (E组 ) 72例 ,食管炎伴发十二指肠球部溃疡患者 (E +DU组 ) 45例 ,30名健康对照者接受胃酸分泌试验、下食管括约肌测压、反流性食管炎相关致病因素多元回归逐步删除 ,自变量对因变量的作用分析。结果 E组患者BAO ,MAO ,PAO低于E +DU组患者 ,E组下食管括约肌压力高于E +DU组 ,而括约肌松弛率低于E +DU组。影响反流性食管炎的3个主要因素排序 ,E组患者依次为下食管括约肌压力 ( 78.5 % ) ,白天反流 ( 9.2 % )和食管裂孔疝 ( 8.7% )。E +DU组患者三个主要影响因素依次为下食管括约肌 ( 4 4.8% ) ,基础胃酸 ( 4 1.5 % )和夜间反流 ( 8.6 % )。结论 胃酸分泌过多时 。
Objective To evaluate the effect of gastric hyperchlorhydria on reflux esophagitis. Methods Seventy-two patients with esophagitis (Group E) and 45 patients with esopagitis and concomitant duodenal ulcer (Group E+DU), diagnosed by endoscopy and introesophageal 24-hour pH monitoring , were enrolled in this study. Thirty normal individuals were in control group. Acid secretory testing, low esophsgeal manometry, multiple regression with stepwise deletion, and percentage of contribution of each independent variable to dependent variable were performed.Results Basal acid output(BAO), maximal acid output(MAO) and peak acid output(PAO) in Group E were lower than those in Group E+DU, and the esophageal sphincter pressure(LESP) were higher than those in Group E+DU. The rank of three main factors affecting reflux esophagitis was LESP(78.5%), day-time reflux(9.2%) and hiatus hernia(8.7%) in Group E, and LESP(44.8%), BAO(41.5%) and night-time reflux(8.6%) in Group E+DU. Conclusion When gastric acid secretion is increased, LES dysfunction and BAO are important factors predisposing to reflux esophagitis.
出处
《广东医学》
CAS
CSCD
2001年第9期801-802,共2页
Guangdong Medical Journal
