摘要
目的 :研究青蒿琥酯贴片的释放规律。方法 :制备青蒿琥酯贴片并测定青蒿琥酯的含量 ,通过体外经皮渗透实验分析累积释放率及释放速率与释放时间的关系。结果 :面积为 10cm2 的贴片青蒿琥酯含量约为 45mg ,青蒿琥酯从贴片中的累积释放率随时间的延长呈增长趋势 ,但释放速率达一定值后趋于恒定。结论 :青蒿琥酯从贴片中的释放规律符合Higuchi方程 。
Objective: To study the releasing rule of Artesunate TDD s (ASTDDs). Methods: To prepare the ASTDDS and determine the content of artesunate, the transdermal experiments are used to study the relation between accumulative releasing ratio or releasing speed and releasing time. Results: The content of artesunate is about 45mg/10cm 2 and the accumulative releasing ratio increases with releasing time, but releasing speed is constant when the releasing speed reached some value. Conclusion: The releasing rule of ASTDDs conforms to Higuchi equation. The ASTDDs can come to durable effect.
出处
《中成药》
CAS
CSCD
北大核心
2001年第8期547-550,共4页
Chinese Traditional Patent Medicine
基金
广东省自然科学基金课题 (No .970 2 2 4)
