摘要
高血压是一种多基因病症 ,传统的化学药物治疗有很多的缺点 ,拟议中的基因治疗方案是针对高血压易感基因设计出反义寡核苷酸 (ASODN) ,将其导入体内后可以阻断特定基因表达 ,从而发挥治疗作用。这种治疗方法的特点是持续时间长、效果好、无副作用。但是由于有一些技术上的难题 。
Hypertension is a disease caused by multiple genes. The traditional treatments have many defects. A gene therapy has been propased where antisense oligonucleotide (AS ODN) is developed to specifically block the expression of hypertension candidate genes. It is of long term effect, high efficiency and non toxicity. Preliminary results are encouraging, but much work needs to be done before gene therapy could be applied to humans.
出处
《生理科学进展》
CAS
CSCD
北大核心
2001年第4期312-317,共6页
Progress in Physiological Sciences
关键词
高血压
基因治疗
反义寡核苷酸
Hypertension
Gene therapy
Antisense oligonucleotide
