摘要
目的 探讨喉癌患者以肺癌为表现的第二原发癌的发病情况、治疗方法及预后。方法总结 2 182例喉癌患者中出现的 36例第二原发肺癌 ,回顾分析喉癌的治疗 (分为单一放疗、单一手术、手术 +放疗 )对发生第二原发肺癌的影响 ,及第二原发肺癌的治疗情况和预后。随访患者均超过 5年 ,随诊率为 10 0 %。生存率用寿命表法计算。结果 36例第二原发肺癌 ,占喉癌患者总例数的1.7% (36 /2 182 ) ;占喉癌第二原发癌的 45 .0 % (36 /80 ) ,而同期 15 5 41例肺癌患者中 ,则没有在喉部发生第二原发癌者。第二原发肺癌多在喉癌确诊后平均 44个月 (1～ 14年 )时发现。 36例中 ,鳞癌 32例 ,腺癌 2例 ,小细胞未分化癌 1例 ,大细胞未分化癌 1例。第二原发肺癌平均生存 2 3个月 ,2年生存率为 41.7% ,5年生存率为 8.3%。结论 喉癌的第二原发癌以肺癌为最多 ,而肺癌很少出现第二原发喉癌。喉癌的治疗方法对肺癌的发生与否及发生时机影响不大 ,手术 +放疗优于单一手术及单一放疗。
Objective To discuss the development, treatment and prognosis of a second primary lung cancer in laryngeal carcinoma patients. Methods A total of 36 patients with a second primary lung cancer was discovered in 2 182 laryngeal cancer patients. For comparison, a group of 15 541 lung cancers was also reviewed for the presence of a second primary laryngeal cancer. All patients have been followed for over five years. Results From 1958 to 1999, out of 2 182 laryngeal carcinoma patients, 36 synchronous (3) or metachronous (33) second primary malignancies of the lung were found. This represented 1.65% of all largngeal cancers observed or 45.0% of all the second primary cancers developed. Their pathology was: squamous cell carcinoma(32 88.9%), adenocarcinoma(2 5.6%), small cell carcinoma(1 2.8%) and large cell carcinoma (1 2.8%). The c TNM stages were: stageⅠ (7 19.4%), stageⅡ(12 33.3%), stageⅢ(9 25.0%) and stageⅣ(8 22.2%). The 2 and 5 year survival rates were 41.7% and 8.3%, with an average survival of 23 months. The interval from the treatment of the initial laryngeal carcinoma to the development of the new second primary carcinoma of lung ranged from 1 to 14 years, with an average of 44 months. Conclusion Synchronous or metachronous second malignancies of the lung are sometimes encountered in laryngeal cancer patients while the occurrence of a laryngeal second primary following a lung cancer is not observed. The development of the second primary lung cancer is not related to the treatment of the initial laryngeal malignancies. Surgery plus external radiotherapy provides better results than surgery or radiotherapy alone.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2001年第4期341-343,共3页
Chinese Journal of Oncology
关键词
喉肿瘤
肺肿瘤
肿瘤
第二原发
Laryngeal neoplasms
Lung neoplasms
Neoplasms,second primary
