摘要
目的 探讨NK/T细胞淋巴瘤的临床病理 ,免疫表型特点及其与EB病毒的关系。方法 用免疫组织化学染色方法 (选用CD3ε、CD5 6等抗体 )确定瘤细胞来源。用原位杂交方法检测EB病毒编码的RNA(EBER1/ 2 )。结果 117例TCL中 2 6例表达NK/T细胞标记 (2 2 .2 % ) ,其中鼻部NK/T细胞淋巴瘤 15例 (5 7.7% ) ;肿瘤细胞的多形性 (18/ 2 6例、6 9.2 % )和凝固性坏死 (12 / 2 6例、46 .2 % )是主要的病理学特点 ;EB病毒感染率 46 .2 % (12 /2 6 ) ,其中鼻部感染率 73 .3% (11/ 15 ) ,非鼻部为 9.1% ,两组比较P <0 .0 0 5。结论 NK/T细胞淋巴瘤常发生在鼻部 ,呈侵袭性生长 ,肿瘤细胞的多形性和坏死是其组织学特点 。
Objective To study the clinicopathologic?immunophenotypic characteristics of NK/T cell lymphomas and association of Epstein Barr virus(EBV) with these disease. Methods The expression of CD3ε?CD56 and presence of EBV encoded RNA(EBER1/2) were detected by immunohistochemistry and in situ hybridization respectively. Results NK/T cell marker was expressed in 26 of 117 (22.2%) T cell lymphomas(TCLs) ,among which there were 15 cases (57.7%) of nasal NK/T cell lymphomas.The major pathologic features of these lymphomas were polymorphism of neoplastic cells( 18/26?69.2% ) and coagulation necrosis( 12/26?46.2% ).The frequency of EBV infection in NK/T cell lymphomas was 46.2% (12/26), including 73.3%(11/15) of nasal and 9.1% of non nasal cases,between which there was a prominent difference(P<0.005). Conclusions NK/T cell lymphomas often involve nasal site and are aggressive.These lymphomas are histologically characterized by polymorphism of tumor cells and necrosis.There is a strong relationship between EBV infection and development of NK/T cell lymphomas. [
出处
《遵义医学院学报》
2001年第4期307-309,共3页
Journal of Zunyi Medical University
基金
贵州省教委基金资助项目 (No .1999 477)
