摘要
目的 探讨白介素 6 (IL 6 )在实验性大鼠脑出血急性期脑组织和血浆中的含量变化 ,阐明其在脑出血过程中的作用 .方法 SD大鼠 80只 ,体质量 2 5 0 30 0g,随机分为 4组 :对照组、小量出血组、中量出血组、大量出血组 .每组又分成 5个小组 ,每小组 4只 .采用Nath法建立脑出血模型 .用放射免疫法测定血浆及脑组织中IL 6的含量 .结果 脑出血后 ,脑组织及血浆中IL 6水平明显升高 (P <0 .0 5 ) ,有随脑出血量增加而增加的趋势 ,出血后不同时间IL 6的水平有显著差别 (P <0 .0 5 ) ,以 48h最高 (P <0 .0 1) .结论 IL 6升高是脑出血损伤后白细胞及中枢神经系统受损的免疫应答改变 ,监测IL
AIM To investigate IL 6 concentration change in brain tissue and plasma after acute cerebral hemorrhage in rats and reveal the action of the IL 6 during the brain bleeding. METHODS Eighty SD rats weighting 250~300 g were divided into four groups. Each group was further divided into five subgroups. The model of acute cerebral hemorrhage was established by Nath method. The concentrations of IL 6 in plasma and brain tissues were measured with radioimmu noassay. RESULTS The levels of LI 6 in plasma and brain tissue in experimental groups remarkably increased ( P <0.05) , tending to increase with the amount of the bleeding. The levels of IL 6 differed at different time points after acute cerebral hemorrhage ( P <0.05), the 48 h being the highest ( P <0.01). CONCLUSION Increasing the levels of IL 6 in plasma and cerebral tissues results in the response of immune system and central nervous system (CNS); measuring the levels of IL 6 is significant for understanding the change of the CNS after cerebral hemorrhage and for judgment of prognosis.
出处
《第四军医大学学报》
北大核心
2001年第15期1409-1411,共3页
Journal of the Fourth Military Medical University
关键词
脑出血
急性
白介素6
血浆
脑组织
cerebral hemorrhage, acute
IL 6
rat
plasma
perihemotoma
