摘要
目的 通过对恶性肿瘤特异性生长因子Tumor specific crowth factor TSGF的检测，为肿瘤疾病的诊断、疗效观察以及判断肿瘤复发转移提供依据。 方法 选择健康人39例，良性肿瘤患者32例，恶性肿瘤患者374例作为研究对象；采用化学比色法测得TSGF浓度。 结果 374例恶性肿瘤患者中有286例表现为阳性，阳性率为76．5％；良性肿瘤及正常人组阳性率分别为12．50％及5．13％。恶性肿瘤患者TSGF检测的特异性为94．87％、诊断效率为78．2％，恶性肿瘤患者TSGF含量与良性肿瘤及正常人相比存在明显统计学差异（P＜0．01）。另对28例恶性肿瘤患者进行治疗前后TSGF测定，治疗前后阳性率由78．59％降至14．82％，两者比较存在显著的统计学意义（P＜0．01）。经临床确诊，治疗后TSGF反而升高的病人均有不同程度的病情恶化和转移发生。 结论 TSGF的检测具有广谱、敏感的优点，有助于良性、恶性肿瘤的区别，为临床恶性肿瘤的诊断，疗效观察以及判断肿瘤复发转移提供了新的检测手段。
Objective To study the clinical signifacance of tumor spacific growth factor TSGF in the differential diagnosis and prognosis of malignant tumors． Method The serum levels of TSGF were determined for 374 cases of malignant tumors, 32 benign tumors and 39 healthy people with chemical colorimetry． Results 286 cases 76．5％ were positive among 374 malignant tumors, and specificity was 98．87％． The positive rate was 12．5％ in benign tumors and 5．13％ in healthy group． There were signifacant difference between the malignant and benign or healthyP＜0．01． The positive rate of before and after therapy in 28 malignant tumors decreased from 78．59％ to 14．2％． It showed a statistical difference． After therapy, the increasing of TSGF prompted the state of exacerbation and metastasis． Conclusion TSGF test it sesitive and broad method． It contributes to distinguish benign and malignant tumor, and observe the curative effect and judge matastatic state of cancer． [
出处
《江西医学检验》
2001年第3期148-150,共3页
Jiangxi Journal of Medical Laboratory Sciences
