摘要
目的 探讨反复呼吸道感染 (RRI)与纤毛结构异常的关系 ,统计此特殊人群中原发纤毛运动障碍 (PCD)的发生率。方法 在纤维支气管镜直视下对临床诊断为RRI的入选患儿行支气管粘膜活检并电镜观察纤毛结构后诊断 ,统计各项异常结构的发生率。结果 有 45 0 % (18/ 40 )的RRI患儿电镜结果存在不同程度的纤毛结构异常 ,结合病史、胸部和副鼻窦X线片有 2 2 5 % (9/ 40 )的患儿诊断为PCD。结论 呼吸道纤毛结构异常是导致儿童RRI的另一重要原因 ,其发生机率远超过原有估计程度 ,其中原发纤毛运动障碍发生率虽低 ,但并非罕见 ,应引起临床重视。
Objective To investigate the relationship between the recurrent respiratory infection and ciliary structure abnormality,and the incidece of cilia structure abnormality in children with recurrent respiratory tract infection.Methods Respiratory ciliated cells were collected by bronchial fibroscopy biopsy,and analyzed by electron microscopy.The incidence of varied cilia structure abnormalities was assessed.Results The ciliary ultrastructure was found to be abnormal in 18 out of 40 patients and PCD was diagnosed in 9 cases.Conclusion Ciliary structure abnormality was an important cause in determining RRI,but the incidence of which was underestimated.It should be noted that primary ciliary dyskinesia was not rare,though the incidence of which was relatively low.
出处
《中国实用儿科杂志》
CSCD
北大核心
2001年第7期405-407,共3页
Chinese Journal of Practical Pediatrics
