摘要
目的 :通过对皮瓣局部放射性核素显像 ,观察血小板活化因子拮抗剂 BN5 2 0 2 1(银杏苦内酯 B)对大鼠任意皮瓣各区段血容量的影响。 方法 :使用 BN 5 2 0 2 1对皮瓣局部进行处理 ,分别于术后 3、6、9h,采用 99m Tc体内标记红细胞的方法对皮瓣局部进行显像、绘制感兴趣区 (ROI)并计算各段皮瓣的摄取比 (U R) ,分别与对照组进行比较。 结果 :使用 BN5 2 0 2 1处理皮瓣局部 ,可使皮瓣中、末段的 UR明显增加 (P<0 .0 1)。 结论 :BN5 2 0 2 1可以减轻皮瓣局部的炎症反应 ,减轻血流阻力 ,改善皮瓣血供。
Objective: To evaluate the effect of platelet activating factor(PAF) antagonism on the blood content in the random survival flap. Methods: A lipophilic PAF receptor antagonist BN52021 was administered to treat flaps through a local subcutaneous injection route 30 min prior to transplantation. The flaps were imaged in situ by a gamma camera. Results: The PAF receptor antagonist significantly augmented the accumulation of radioactivity of middle and end part within treated flaps( P <0.01). Conclusion: The specific platelet activating factor receptor antagonist BN52021 is able to diminish the accumulation of acute inflammatory cells directly or indirectly, and is beneficial to the hemodynamic balance of the total flap. [
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2001年第7期675-676,共2页
Academic Journal of Second Military Medical University
