摘要
目的 研究雌激素受体 (ER)在胃癌中的表达 ,探讨其与组织学分类、Borrmann分型及转移的关系。方法 运用链酶菌亲生物素 -过氧化酶连结法检测 2 0例正常粘膜、2 0例不典型增生与 91例胃癌中ER表达。结果 ER表达阳性率 ,正常胃粘膜与不典型增生全部阴性 ,胃癌为 38% (35 /91) (P <0 .0 5 )。其中 ,高分化腺癌 10 % (3/30 )分别低于低分化腺癌 43% (13/30 )、未分化癌 5 3% (8/15 )、粘液癌 6 3% (5 /8)及印戒细胞癌 75 % (6 /8) ,皆具有显著性差异 (P<0 .0 5 ) ;Borrmann分类 ,Ⅲ +Ⅳ型 5 6 % (2 4/4 3)明显高于Ⅰ型 2 2 % (4 /18)和Ⅱ型 2 3% (7/30 ) (P <0 .0 5 ) ;淋巴结转移5 5 % (2 8/5 1)与未转移 2 3% (9/4 0 )的差异有显著性 (P <0 .0 5 ) ;而与性别、年龄无关。结论 ER表达阳性是胃癌生物学标志之一 ,且与其分化程度、Borrmann分类、浸润转移有关 ,提示ER阳性胃癌预后差 ,但可采取内分泌治疗。
Objective To study the relationship between the expression of estrogen receptor(ER) and histopathological classification,Borrmann′s types and metastasis.Methods The expression of ER in 20 cases of normal gastric mucosa,20 cases of atypical gastric mucosa and 91 cases of gastric carcinoma were examined by streptoavidin-peroxidase conjugated method(SP).Results ER was absent in normal and atypical gastric mucosa,and ER positive rate was found in 38%(35/91) of gastric carcinoma (P<0.05).ER positivity was 10%(3/30) in well-differentiated gastric carcinoma,which was significantly lower than 43%(13/30) in the poorly-differentiated,53%(8/15) in the undifferentiated,63%(5/8) of mucoid carcinoma and 75%(6/8) of signet ring cell carcinoma,respectively(P<0.05).The positive rate of ER in Borrmann Ⅲ+Ⅳ(56%) was higher than that in Borrmann Ⅰ(22%) and Ⅱ(23%) (P<0.05).There was obvious difference of ER expression between lymph node metastasis (55%) and nonlymph node metastasis (23%) in gastric carcinoma(P<0.05).The was no correlation between ER positive rate and age or sex.Conclusion Positive expression of ER is a biologic marker in gastric carcinoma,and related to the degree of differentiation,infiltration and metastasis,which suggests that ER-positive gastric carcinoma has a poor prognosis,but may be effectively treated by endocrine therapy.
出处
《中国肿瘤临床与康复》
2001年第4期26-27,25,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
基金
湖南省卫生厅"八
五"重点项目科研基金资助 (NO 930 1)
关键词
雌激素受体
表达
胃癌
病理
stomach tumor
estrogen receptor
expression
clinicopathological feature
