摘要
目的 :观察养肺活血汤的抗炎作用及其对炎症介质的影响。方法 :分别用致炎剂二甲苯、角叉菜及纸片包埋法造成小鼠和大鼠的炎症模型 ,以气管注射博莱霉素复制大鼠肺纤维化模型 ,在此基础上研究养肺活血汤对各类炎症反应的抑制作用 (肿胀率、肿胀程度、肉芽肿重量 ) ,以及对血中组胺、肿瘤坏死因子含量的影响。结果 :养肺活血汤对急性、亚急性、慢性炎症均有显著的抑制作用 (P <0 .0 1) ,并能明显降低肺纤维化模型大鼠血中组胺和肿瘤坏死因子的含量 (P <0 .0 1,P <0 .0 5 )。结论 :影响炎症介质的分泌 ,减轻炎症损伤 。
Objective:To observe the anti inflammatory action of Yangfeihuoxue Decoction and its effects on inflammatory mediums. Methods: The mouse and rat inflammatory models were established by dimethylbenzene, carrageenin and paper strip investing method, and the rat model of pulmonary fibrosis was established by bleomycin. The inhibition of Yangfeihuoxue Decoction on various inflammatory reactions (with swelling rate, swelling degree and height of granuloma as markers) and its effects on levels of histamine (H) and tumor necrosis factor (TNF) in blood were studied. Results: Yanfeihuoxue Decoction can obviously inhibit acute, subacute and chronic inflammatory disease ( P <0.01) and reduce levels of H and TNF in blood of rat model with pulmonary fibrosis ( P<0.01, P<0.05 ). Conclusion: It may be one of important mechanisms that yangfeihuoxue Decoction prevents and treats pulmonary fibosis by affecting the secretion of inflammatory mediums and reducing inflammatory damage.
出处
《中成药》
CAS
CSCD
北大核心
2001年第7期511-514,共4页
Chinese Traditional Patent Medicine
关键词
养肺活血汤
抗炎
肺纤维化
炎症介质
Yangfeihuoxue Decoction
anti inflammatory action
pulmonary fibrosis
inflammatory mediums
