摘要
目的 :观察老年冠心病心衰患者血浆白细胞介素 - 6 (Interleukin - 6 ,IL - 6 )及一氧化氮 (NitricOxide,NO)浓度的变化。方法 :选择 48例老年冠心病心衰患者和 30例健康老年人 ,测定其血浆IL - 6、NO浓度。结果 :心衰组血浆IL - 6浓度 (19.81± 15 .9)pg/ml明显高于对照组 (7.0 2± 2 .36 ) pg/ml,P <0 .0 0 1) ,NO浓度(73.39± 35 .49) μmol/L明显高于对照组 (4 2 .82± 17.2 4) μmol/L ,P <0 .0 0 1。心衰组血浆IL - 6和NO浓度与左室射血分数 (LVEF)呈负相关 (r分别为 - 0 .6和 - 0 .37,均P <0 .0 1) ,血浆NO浓度与IL - 6浓度呈正相关 (r =0 .0 6 ,P <0 .0 0 1)。结论 :老年冠心病心衰血浆IL - 6、NO浓度明显升高 ,二者随心衰加重而升高。IL -
Objective:The aim of this study was to observe the concentration of plasma interleukin-6(IL-6) and Nitric Oxide(NO) in elderly patients with heart failure secondary to conronary artery disease (CAD).Methods:A comparison of the plasma levels of IL-6 and NO was made between 48 patients with heart failure secondary of CAD and 30 normal subjects.The concentration of plasma IL-6 and NO were measured.Results:Plasma Levels of IL-6 were higher in patients with heart failure (19.81±15.89pg/ml)compared with control (7.02±2.36pg/ml,P<0.001).Plasma leves of NO were higher in patients with heart failure (73.39±35.49μmol/L)compared with control (42.82±17.24μmol/L,P<0.001).There was a negative correlation between conceentrations of IL-6 and NO each and left ventricular Ejection fraction(LVEF)(r=-0.60,P<0.01;r=-0.37,P<0.01 respectively).the was a significantly correlation between IL-6 and NO (r=0.60,P<0.001).Conclusions:Our findings indicate that concentration of both IL-6 and NO were elevated in elderly patient with heart failure secondary to CAD.The severer heart failure is,The higher the concentration of IL-6 and NO are,which suggest an important role for IL-6 and NO in the pathophsiology of heart failure.
出处
《中国现代医学杂志》
CAS
CSCD
2001年第7期58-59,共2页
China Journal of Modern Medicine
关键词
冠心病
心力衰竭
白细胞介素-6
一氧化氮
老年人
Coronary Artery Disease
Heart Failure
Interleukin-6
Nitric Oxide
Elderly Patient
