摘要
用细胞质分裂阻断微核技术（简称ＣＢ微核法）研究了癌细胞的放射敏感性，结果表明；ＣＢ 微核法可用来预测癌细胞对重离子和γ射线的放射敏感性，具有省时且成功率高的特点。细胞 受重离子作用后，每双核细胞的微核与剂量的效应关系适合方程 Y＝ c＋ ｋＤｎ或 Y＝ｃ＋ａＤ＋βＤ２，受γ射线作用后，每双核细胞的微核与剂量的效应关系适合方程 Y＝ｃ＋ ａＤ。在相同剂量下，重离子效应高于ｒ射线效应。
Radiosensitivity of tumor cells was studied by the Cytokinesis-Block(CB) micronucleus assay. The results show that radiosensitivity of tumor cells induced by heavy ions and y -rays can be predicted with CB technique, it has the advantages of time saving and higher possibility of success. The dose response for micronuclei per binucleated cells is given by Y= c + kD^n or Y= c + aD+ AD^2 when treated with heavy ions, and given by Y= c + aD in the case ofγ -rays. Under the same dose, effectiveness of heavy ions is stronger than that of γ -rays.
出处
《核技术》
CAS
CSCD
北大核心
2000年第3期187-190,共4页
Nuclear Techniques
基金
九五国家"攀登计划(B)"项目!950603
