摘要
本文研究了玻璃纤维对机体的生物学作用。实验分两部分,体外实验检测玻璃纤维对肺泡巨噬细胞的毒性和对红细胞的溶血作用。体内实验用大鼠气管内注入玻璃纤维30mg,定期宰杀动物,称肺重,肺和淋巴结做病理检查,测定肺组织总脂、类脂和胶原蛋白的含量。结果表明玻璃纤维对肺泡巨噬细胞毒性较低,对红细胞膜的损伤作用较轻微。动物染尘18个月肺部出现轻度间质纤维化。肺内胶原及脂质成份增长速度较慢。作者认为玻璃纤维的生物学作用较弱,长期吸入对人体有危害作用,有可能引起尘肺。实验发现玻璃纤维能诱发肿瘤,用玻璃纤维代替石棉,使用的安全问题应予重视。
This paper deals with the biological effects of glass fibers in vitroand in vivo. The toxic effect of glass fibers on alveolar macrophages andtheir hemolytic action on erythrocytes were determined in vitro. In vivotests 30 mg glass fiber suspension was introduced into the lungs of rats byintratracheal instillation. The animals were killed at different intervalsup to 18 months. The lungs were weighed and divided into 2 parts for to-tal lipid and collagen assay and histological examination. The results of thisstudy showed that the cytotoxicity and hemolysis effect of glass fiber werelow. Pulmonary lesions in rats after 18 months developed slight interstitialfibrosis. The increase in lung weight, total lipid and collagen content wasat a low level. It was concluded that the biological effects of glass fiberwere weak. Long-term exposure to glass fiber may cause health hazards orpneumoconiosis. In addition, this experimental study suggested that glassfiber induced tumor in some animals, the main neoplasm was pulmonaryadenocarcinoma. When glass fibers are used as a substitute for asbestos,attention is still required to safety of application.
出处
《解放军预防医学杂志》
CAS
北大核心
1991年第1期25-29,共5页
Journal of Preventive Medicine of Chinese People's Liberation Army
关键词
玻璃纤维
肺泡
巨噬细胞
红血球
glass fiber
asbestos
alveolar macrophages
erythrocytes
